PHYS 3650L=
-
Modern Physics Laboratory
Laboratory
Advanced Sheet
Radiation C=
ancer
Treatment Planning
1.
Objectives. The objective of this laboratory is to create an intensity modula=
ted
radiation treatment (IMRT) plan for prostate cancer case by using the Hyper=
ion
treatment planning system.
2. Theory.
Hyperion is an I=
MRT
planning system which optimizes a treatment plan by using Monte-Carlo stimu=
lation
method. The analysis of the p=
lan is
then based on the dose volume histograms (DVH) calculated for a chosen geom=
etry
(5-beam in our case). Dose volume histrograms w=
ill be
calculated for the primary target volume, and three organs at risk: bladder,
rectum, and skin. =
To evaluate the =
quality
of a plan we will use Lyman-Kutcher-Burman (LKB)
model to calculate the normal tissue complication probabilities (NTCP): the
probability that a certain percentage of the patient population will incur
unfavorable reactions at a particular dose.
![](3D"Phys3650L.Hyperion_files/image002.gif")
![](3D"Phys3650L.Hyperion_files/image004.gif")
![](3D"Phys3650L.Hyperion_files/image006.gif")
where the following
parameters will be used:
|
Organ =
|
n=
|
m=
|
TD50
(Gy)
|
|
Rectum=
|
0.12
|
0.15
|
80
|
|
Bladde=
r
|
0.13
|
0.11
|
62
|
3. Apparatus and experimental proce=
dures.
a. Equipmen=
t.
1)
Computer.
2)
Hyperion planning system.
b. Procedur=
es.
Detailed instructions are provided in paragraph 4 below.
4. Requirements.
a. In the laboratory.
1)
Your instructor will introduce you to the Hyperion program.
2)
Create a 5-beam treatment plan.
3)
Display and read DVHs for primary target volime and organs at risk.
4)
Analyze the NTCP’s calculated for the 5-b=
eam
treatment plan.
b. After the laboratory. A laboratory report is =
not required for this experimen=
t.
=
=
=
=
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