Dr. Jordan's Research Page

Research Interest:

My academic interests include the areas of environmental and inhalation toxicology.   My research involves 1) examining the roles of cytokines, chemokines, and antioxidant enzymes in mediating acute lung injury 2) developing  "state of the art" in vitro tests for evaluating the toxicity associated with environmental agents. 

Current Research Project:

In conjunction with the National Aeronautics and Space Administration (NASA), I am developing tissue culture models to evaluate the toxicity associated with various chemicals and radiation.  During space missions, astronauts are potentially exposed to a complex environment of radiation and chemicals.  Many of these agents are known to be mutagenic and carcinogenic to humans.  The risk associated with long-term space exploration is unknown.  The effects to various organ systems must be determined.  The overall goal of this project is to develop more tissue-like model systems to evaluate the toxicity associated with space exploration and extrapolate the risk to humans.  These newly developed models can be used by researchers to evaluate the exposure to potentially toxic agents.

Publications:

Jordan JA, Fraga DN, Gonda SR.  Development of Three-Dimensional Tissue Culture Model for Mutagenic Analysis.  In Vitro Biology-Animal.  In Final Revision. 2002 

Jordan  JA, Guo RF; Yun EC; Sarma V Warner RL, Crouch LD, Senaldi G, Ulich TR, and Ward, PA.  Role of IL-18 in Acute Lung Injury.  Journal of Immunology, 2001, Dec. 15, Vol 167 (12), pp. 7060-8.

Martinez-Mier G, Toledo-Pereyra LH, Bussell S, Gauvin J, Vercruysse G, Arab A, Harkema JR, Jordan JA, and Ward PA.  Nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion injury. Transplantation, 2000, Nov. 27, Vol. 70 (10), pp. 1431-7.

Ramos-Kelly JR, Toledo-Pereyra LH, Jordan J, Rivera-Chavez F, Rohs T, Holevar M, Dizon RA, Yun E, Ward PA. Multiple selectin blockade with a small molecule inhibitor downregulates liver chemokine expression and neutrophil infiltration after hemorrhagic shock. Journal of Trauma. 2000, Jul.  Vol. 49 (1), pp. 92-100.

Guo RF, Ward PA, Jordan JA, Huber-Lang M, Warner RL, and Shi MM.  Eotaxin expression in Sephadex-induced lung injury in rats. American Journal of Pathology. 1999, Dec. Vol. 155 (6), pp. 2001-8.

Ramos-Kelly JR, Toledo-Pereyra LH, Jordan JA, Rivera-Chavez FA, Dixon RA, and Ward PA.  Upregulation of lung chemokines associated with hemorrhage is reversed with a small molecule multiple selectin inhibitor.  Journal of the American College of Surgeons. 1999, Dec. Vol. 189 (6), pp. 546-53.

Lentsch AB, Crouch LD, Jordan JA, Czermak BJ, Yun EC, Guo R, Sarma V, Diehl KM, and Ward PA. Regulatory effects of interleukin-11 during acute lung inflammatory injury. Journal of Leukocyte Biology. 1999, Jul, Vol 66, pp. 151-7.

Lentsch AB, Czermak BJ, Jordan JA, and Ward PA.  Regulation of Acute Lung Inflammatory Injury by Endogenous IL-13. Journal of Immunology. 1999, Jan 15, Vol 162 (2), pp. 1071-6.

Lentsch AB, Jordan JA, Czermak BJ, Diehl KM, Younkin EM, Sarma V, and Ward PA. Inhibition of NF-kappaB activation and augmentation of IkappaBbeta by secretory leukocyte protease inhibitor during lung inflammation. American Journal of Pathology. 1999. Jan, Vol. 154 (1), pp. 239-47.