Exam and Quiz Information
Provisional Study Guide for Final Exam
Take Home Questions (worth 40 pts) are due July 30 by 5pm and will be based on:
What are the different types of muscle fibers the researchers describe and what are their characteristics? (4 pts)
Describe the experiments the scientists used on the gastrocnemius muscle. Why did they choose the gastrocnemius muscle? (4 pts)
Describe the transgenic mouse the researchers developed for their study and their rationale for developing this kind of mouse. (5 pts)
The researchers describe three ways to activate PPARd (1536-1537). Produce diagrams that show these three pathways. (3 pts)
CHOOSE ONE:
Attendant with the changes in mitochondria are changes in motor neuron function. Design an experiment that could test for that type of change. (10 pts)
The scientists mention that currently they do not know how PPARd affects glucose metabolism. Does it play a role in insulin resistance? Design an experiment that could test its possible role in insulin resistance. (10 pts; extra points for well designed experiments)
Frey and Morris, (1997) Synaptic tagging and long term potentiation
- Describe what occurs to produce late term LTP. (3 pts)
- Describe the experimental setup and their results. (5 pts)
- What kind of proteins would need to be synthesized to strengthen a synapse? (6 pts). This question requires you to search the literature since it has been 12 years since this article was published, there may be information on what kind of proteins are synthesized.
Exam 3: July 22. Review session Tuesday July 21 in Faculty Hall, Suite 16 3:00 to 4:00pm.
Exam 2: July 8. Review session Tuesday, July 7 in Faculty Hall, Suite 16 3:00 to 4:00pm.
Take Home Questions
Quiz 1: July1 NIA Review
Exam 1: June 17. Review session Tuesday, June 16 in Faculty Hall, Suite 16 3:00 to 4:00pm.
Take Home Questions: MAKE SURE YOU CITE YOUR SOURCES!!!!! See the
McMillan book, chapter 6, if you do not know how to cite a source.
Not properly citing is plagiarism.
1. Read the journal article,
Seibel, B. A. (2006) On the depth
and scale of metabolic rate variation: scaling of oxygen consumption and
enzymatic activity in the Class Cephalopoda (Mollusca) J. Exp Biol.
210:1-11 and answer the following
questions.
- Identify the hypothesis of this study and indicate whether the hypothesis was supported or not.
- Is Seibel interested in mechanism, origin or both in his study of variation in metabolic rate? Explain your reasoning.
- Seibel discusses a "metabolic theory of ecology" or MTE, which is essentially what was discussed in our text, that supports a universal scaling coefficient How did his study on cephalopods undermine aspects of this theory and what alternative explanations did he produce to explain the differences between epipelagic squid and octopods that live deeper in the water column?
2. Summarize the three different theories that attempt to explain the allometric relationship between body size and metabolic rate and then discuss how the Seibel and the Brown et al. papers either support or refute these different theories. Make sure you have very clearly supported information to present in your discussion. I am looking for clear thinking!
3. Design an experiment that takes into account what you have learned from both the Seibel and Brown et al. articles that would support one of the three different theories that you summarized in question #2. Please include the following sections in your design.
- A brief introduction that includes some background and the larger question.
- Hypothesis
- Methods that you will use. Include controlled variables, dependent variables and independent variables.
- Indicate what you will measure to collect your data.
- What are your predictions for the experiment.